Journal of Medicinal Chemistry p. 2231 - 2239 (1990)
Update date:2022-07-29
Topics:
Barraclough
Black
Cambridge
Collard
Firmin
Gerskowitch
Glen
Giles
Hill
Hull
Iyer
King
Kneen
Lindon
Nobbs
Randall
Shah
Smith
Vine
et al.
A series of 'A' ring substituted sulmazole and isomazole analogues have been prepared and evaluated as inotropic agents. pK(A)'s, protonation sites, and log P values were measured for selected compounds and their electronic properties were calculated. No simple correlation between inotropic activity and pK(A), protonation site, or log P value was observed. However, in vitro inotropism did correlate with the calculated charge density of the 'B' ring imidazo nitrogen atom. The 6-position of sulmazole appeared to be the most tolerant toward substituents, th 6-amino derivative 7 being a more potent inotrope than sulmazole itself. 4-Methoxyisomazole 13 had comparable in vivo inotropic properties to those of isomazole.
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Doi:10.1002/jhet.5570270250
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(1989)Doi:10.1039/c0cc04660d
(2011)Doi:10.1016/j.bmcl.2010.12.064
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