Journal of Antibiotics p. 216 - 224 (1994)
Update date:2022-08-05
Topics:
Fujita
Inoue
Yamamoto
Ikumoto
Sasaki
Toyama
Yoneta
Chiba
Hoshino
Okumoto
In order to investigate the structure-activity relationships, fourteen derivatives of myriocin ((2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyl-14- oxoeicos-6-enoic acid) were prepared and examined for immunosuppressive activity on mouse allogeneic mixed lymphocyte reaction in vitro. Among them, 14-deoxomyriocin ((2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyleicos -6-enoic acid) was the most potent. It also suppressed the generation of allo-reactive cytotoxic T lymphocytes in mice upon intraperitoneal administration, with a potency 10-fold greater than that of myriocin.
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