Archiv der Pharmazie p. 287 - 294 (1990)
Update date:2022-09-26
Topics:
Rehse
Puchert
Leissring
Eleven lipophilic derivatives of the title biogenic amines and 28 structurally related triamines and tetramines have been synthesized. Twenty-three of them inhibited the platelet aggregation induced by collagen at an IC50 between 8 mumol/L and 30 mumol/L. Five compounds prolonged the one stage thromboplastin time (Quick) by 7s or more at 100 mumol/L. The antiplatelet and anticoagulant effect do not run parallel. The relationship between the effects observed and the chemical structure of the oligoamines has been elucidated.
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Doi:10.1021/jo102577a
(2011)Doi:10.1039/jr9470000080
(1947)Doi:10.1021/ol200558j
(2011)Doi:10.1039/DT9900001093
(1990)Doi:10.1021/jm101597x
(2011)Doi:10.1021/jm101623p
(2011)