Journal of Organic Chemistry p. 4264 - 4268 (1991)
Update date:2022-08-04
Topics:
Soai, Kenso
Yokoyama, Shuji
Hayasaka, Tomoiki
The chiral N,N-dialkylnorephedrine-catalyzed addition of dialkylzincs to aliphatic and aromatic aldehydes afforded secondary alcohols of high optical purity (to > 95percent ee).Among the N,N-di(primary alkyl)norephedrines, N,N-di-n-butylnorephedrine (DBNE, 3d) was found to be the most effective catalyst. 1-Phenyl-2-(1-pyrrolidinyl)propan-1-ol (3i) and N,N-diallylnorephedrine (3j) were also highly effective catalysts.The method described provides optically active secondary aliphatic alcohols of high optical purity which cannot be prepared by conventional methods.
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Doi:10.1016/S0040-4039(01)93741-4
(1989)Doi:10.1055/s-0030-1258341
(2011)Doi:10.1055/s-1990-26873
(1990)Doi:10.1021/jo201036x
(2011)Doi:10.1021/jo00305a001
(1990)Doi:10.1007/BF00808929
(1990)