Synthesis p. 295 - 299 (1990)
Update date:2022-08-02
Topics:
Thornton, Timothy J.
Jarman, Michael
Methyl 2,6-difluoro-4-(pivaloylamino)benzoate (3) and the corresponding 4-(tert-butoxycarbonylamino)-analogue 6 have been synthesised by reacting the appropriate 3,5-difluoroaniline derivatives with butyllithium followed by methyl chloroformate.N-(tert-Butoxycarbonyl)-2,3-difluoroaniline (9) required the "super-basic" butyllithium/potassium tert-butoxide mixture to convert it into methyl 4-(tert-butoxycarbonylamino)-2,3-difluorobenzoate (14): the 2,5-difluoro-analogue was formed in a similar manner.In all cases the regiocontrol of metallation was directed by fluorine rather than by the amide substituent.
View MoreContact:+86-571-86025531 / 86024803
Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Contact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
website:https://www.bocsci.com/
Contact:1-631-485-4226
Address:Ramsey Road
website:http://www.fwdchem.com
Contact:86-21-54450828
Address:Room 802,Lotus Tower ,159 Tianzhou Road,Xuhui District,Shanghai
Shijiazhuang Haitian Amino Acid Co., Ltd.
Contact:+86-311-88908111
Address:Shijiazhuang Hebei province,China
Doi:10.1071/CH10471
(2011)Doi:10.1002/anie.201507320
(2015)Doi:10.1007/BF00607561
(1990)Doi:10.1021/ic200387n
(2011)Doi:10.1055/s-0030-1259289
(2011)Doi:10.1055/s-1991-26617
(1991)