Tetrahedron p. 3101 - 3110 (1990)
Update date:2022-08-05
Topics:
Kumar, Ajit
Walker, Richard T.
The synthesis of a series of 2,3-seconucleoside analogues related to nucleosides previously shown to possess anti-HIV activity is described. Using strategies to distinguish between the three primary hydroxyl groups of a 2,3-seconucleoside, 3-azido-2,3-dideoxy-2,3-secothymidine and 2,3-dideoxy-2,3-secothymidine have been prepared. These compounds, several of the intermediates in their synthesis, as well as O22-anhydro-3-azido-3-deoxy-2,3-secothymidine and several 2,3-secouridine analogues have been tested for their ability to prevent infection of cells by HIV. None showed any significant toxicity or antiviral activity.
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Doi:10.1016/S0040-4039(98)00438-9
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