Tetrahedron Letters p. 1471 - 1475 (2019)
Update date:2022-08-02
Topics:
Szabó, Tímea
Hazai, Viktor
Volk, Balázs
Simig, Gyula
Milen, Mátyás
The total synthesis of four natural products, trigonostemine A, trigonostemine B, pityriacitrin, and hyrtiosulawesine was accomplished. The key intermediates, variously substituted 1-formyl-β-carbolines, were prepared in five steps via a novel synthetic approach using readily available starting materials. These formyl derivatives were then further transformed, providing a general route for the synthesis of the four title alkaloids. The method reported herein represents the first total synthesis of the two trigonostemines and a new pathway to pityriacitrin and hyrtiosulawesine.
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