In conclusion, we have developed a new stereoselective
synthesis of trisubstituted alkenes, which is based on gold(I)-
catalyzed regio- and stereoselective hydrophosphoryloxylation
of haloalkynes and subsequent transition-metal-catalyzed
cross-coupling reactions. The present approach provides an
easy access to structurally diverse trisubstituted alkenes and
will find many useful applications.
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SK acknowledges financial support from Nanyang
Technological University and PHL thanks the CRI Program
(2011-0009011) funded by the National Research Foundation
of Korea (NRF), an NRF grant funded by the Korean
government (MEST 2009-0087013), and the 2nd phase BK21
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