The Journal of Organic Chemistry
ARTICLE
’ ACKNOWLEDGMENT
(10) (a) Johnston, K. A.; Allcock, R. W.; Jiang, Z.; Collier, I. D.;
Blakli, H.; Rosair, G. M.; Bailey, P. D.; Morgan, K. M.; Kohno, Y.; Adams,
D. R. Org. Biomol. Chem. 2008, 6, 175. (b) Meyers, C.; Yꢁa~nez, M.;
Elmaatougi, A.; Verhelst, T.; Coelho, A.; Fraiz, N.; Lemiꢂere, G. L. F.;
Laguna, R.; Cano, E.; Maes, B. U. W.; Sotelo, E. Bioorg. Med. Chem. Lett.
2008, 18, 793.
(11) For reviews dealing with Pd-catalyzed reactions on halopyr-
idazines and halopyridazin-3(2H)-ones, see: (a) Maes, B. U. W.;
Koꢀsmrlj, J.; Lemiꢂere, G. L. F. J. Heterocycl. Chem. 2002, 39, 535. (b)
Maes, B. U. W.; Tapolcsꢁanyi, P.; Meyers, C.; Mꢁatyus, P. Curr. Org. Chem.
2006, 10, 377. (c) Maes, B. U. W. In Palladium in Heterocyclic Chemistry;
Li, J. J., Gribble, G. W., Eds.; Elsevier: Amsterdam, 2006; Vol. 26
(Tetrahedron Organic Chemistry Series), p 541.
This work was supported by the Fund for Scientific Research-
Flanders (FWO-Vlaanderen), the Agency for Innovation by
Science and Technology in Flanders (IWT-Vlaanderen) (Ph.D.
scholarship for T.V.), the Hercules foundation, and E. I. du Pont
de Nemours and Co. We thank Prof. Matthias Zeller of Youngs-
town State University and Dr. Christophe Vande Velde of Karel
de Grote University College for the collection of X-ray data sets.
The diffractometer was funded by NSF Grant No. 0087210,
Ohio Board of Regents Grant No. CAP-491, and YSU.
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dx.doi.org/10.1021/jo201009m |J. Org. Chem. 2011, 76, 6670–6677