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Scheme 2 Palladium-catalyzed reaction of 2-alkynylchlorobenzene 4
with 2-alkynylaniline 2.
synthesis of 11H-indeno[1,2-c]quinolin-11-ols. Not only
2-alkynylbromobenzenes but also 2-alkynylchlorobenzenes
are suitable partners in this transformation. This cascade
reaction provides a good example for the introduction of
molecular diversity and complexity with high efficiency and
selectivity. Exploration of other transformations of 2-alkynyl-
halobenzenes is in progress in our laboratory.
Financial support from National Natural Science Foundation
of China (No. 21032007) is gratefully acknowledged.
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c
This journal is The Royal Society of Chemistry 2011
Chem. Commun., 2011, 47, 8967–8969 8969