Organic Letters
Letter
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(19) For conditions for the amino acid fluorides synthesis, see
(20) Our mechanistic data indicate that SCF2 is not spontaneously
liberated from the salt but instead requires activation by the substrate.
For alternative SCF3 sources, a potential liberation of SCF2 has
previously been proposed. See: (a) Liu, J. B.; Xu, X. H.; Chen, Z. H.;
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(21) ReactIR conditions for the three electronically different acids:
under air atmosphere, the carboxylic acid (0.3 mmol, 1 equiv) was
dissolved in DCM (1.5 mL). (Me4N)SCF3 (0.33 mmol, 58 mg, 1.1
equiv) was added in one portion at room temperature under stirring, and
the progress of the reaction was followed by ReactIR (the probe was
additional information.
D
Org. Lett. XXXX, XXX, XXX−XXX