10.1002/asia.201900620
Chemistry - An Asian Journal
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2cb was isolated in 70% yield (Scheme 6a). Similarly, dodecane thiol (1i) and
ethyl mercaptan 1m led to 4im in 79% yield (Scheme 6b). The reaction
proceeded via a stable sulfenium ion from the more electron rich thiol.
Therefore, the selectivity for the unsymmetrical disulfide formation was also
observed for the aliphatic thiols.
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Scheme 6. a) and b) Large scale synthesis of unsymmetrical disulfides. c)
Simultaneous synthesis of two unsymmetrical disulfides.
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A.P. and K.C. thank NISER, Bhubaneswar for fellowships. We are
also thankful to CSIR for funding. We are also thankful to CSIR
for funding (Project No. 02(0338)/18/EMR-II dated 24-04-2018).
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Keywords: DMAP-water as promoter• 1,2-Diaryldisulfanes•
Sulfenium ion• Unsymmetrical disulfides• Weak Interactions
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