Journal of the American Chemical Society
COMMUNICATION
(7) For an excellent review of organocatalytic enantioselective acyl-
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In summary, we have described the first catalytic enantio-
selective desymmetrization of meso-1,2-diaryl-1,2-diaminoethanes
by monobenzoylation. The cooperative action of two catalysts,
DMAP as an achiral nucleophilic catalyst and amideÀthiourea 1a
as a chiral anion receptor catalyst, afforded the monoacylated
products in good yields with good to excellent enantioselectivities.
Further applications of this dual catalyst approach are currently
being investigated.
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’ ASSOCIATED CONTENT
(10) For an enzymatic desymmetrization of cis-1,2-cyclohexanedi-
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S
Supporting Information. Complete ref 3c, experimental
b
procedures, characterization data, and the X-ray crystal structure
of compound 7 (CIF). This material is available free of charge via
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’ AUTHOR INFORMATION
Corresponding Author
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’ ACKNOWLEDGMENT
Financial support from Rutgers, The State University of
New Jersey, is gratefully acknowledged. We thank Dr. Tom
Emge for crystallographic analysis. D.S. is a fellow of the Alfred
P. Sloan Foundation and the recipient of an Amgen Young
Investigator Award.
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