Med Chem Res (2012) 21:2072–2078
2077
selective CCK1R agonists for the treatment of obesity. Bioorg
Med Chem Lett 18:4833–4837
Choudhary MI, Rahman A, Thomsen WJ (2001) Bioassy techniques
for drug development. Harwood Academic Publishers, The
Netherlands, p 22
Chrysselis MC, Rekka EA, Kourounakis PN (2000) Hypocholestero-
lemic and hypolipidemic activity of some novel morpholine
derivatives with antioxidant activity. J Med Chem 43:609–612
Cunico W, Gomes CRB, Moreth M, Manhanini DP, Figueiredo IH,
Penido C, Henriques MGMO, Varotti FP, Krettli AU (2008)
Synthesis, antimalarial evaluation and molecular modeling
studies of hydroxyethylpiperazines, potential aspartyl protease
inhibitors, Part 2. Eur J Med Chem 44:3816–3820
David J, Wager E (1998) Haematological safety of antipsychotic
drugs. J Psychopharmacol 12:283–288
Drizin I, Werness S, Krafte DS, Jarvis MF, Faltynek CR, Kort ME
(2008) Discovery of potent furan piperazine sodium channel
blockers for treatment of neuropathic pain. Bioorg Med Chem
16:6379–6386
Kumar M, Rathore BS (2006) Synthesis of 7-chloro-5-trifluoro-
methyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as anti-
microbial agents. Bioorg Med Chem 14:5678–5682
Li JB, Xia L, Wu B, Wang T, Jiang ZZ (2008) Design, synthesis and
biological estimation of 1-(benzoxazole-2-yl) piperazine and 4-
(benzoxazole-2-yl) piperidine derivatives as potential a1-AR
antagonists. Chin Chem Lett 19:1193–1195
Li HQ, Zhu TT, Yan T, Luo Y, Zhu HL (2009) Design, synthesis and
structure–activity relationships of antiproliferative 1, 3-disubsti-
tuted urea derivatives. Eur J Med Chem 44:453–459
Ma Y-T, Huang M-C, Hsu F-L, Chang H-F (1998) Thiazinedione
from xanthium strumarium. Phytochemistry 48:1083–1085
Macchiarulo A, Costantino G, Fringuelli D, Vecchiarelli A, Schiaf-
fella F, Fringuelli R (2002) 1,4-Benzothiazine and 1,4-benzox-
azine imidazole derivatives with antifungal activity: a docking
study. Bioorg Med Chem 10:3415–3423
Mahmoud AA, Ahmed AA, Al-Shihry SS, Spring O (2005) A new
heterocyclic glucoside from the fruits of Xanthium pungens. Nat
Prod Res 19:585–589
Fogla AK, Ankodia V, Sharma PK, Kumar M (2009) N-bridged
heterocycles: regiospecific synthesis of 2-methyl-4H-pyrimi-
do(2,1-b benzothiazol-4-ones. Res Chem Intermed 35:35–41
Folkes AJ, Wiesmann C, Workman P, Zhyvoloup A, Shuttleworth SJ
(2008) The identification of 2-(1H-Indazol-4-yl)-6-(4-methane-
Masson M, Holappa J, Hjalmarsdottir M, Runarsson OV, Nevalainen
T, Jarvinen T (2008) Antimicrobial activity of piperazine
derivatives of chitosan. Carbohydr Polym 74:566–571
Matysiak JJ (2006) Synthesis, antiproliferative and antifungal activ-
ities of some 2-(2,4-dihydroxyphenyl)-4H-3,1-benzothiazines.
Bioorg Med Chem 14:2613–2619
sulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,
2-
d]pyrimidine (GDC-0941) as a potent, selective, orally bioavail-
able inhibitor of class I PI3 kinase for the treatment of cancer. J
Med Chem 51:5522–5532
Minarini A, Marucci G, Bellucci C, Giorgi G, Tumiatti V, Bolognesi
ML, Matera R, Rosini M, Melchiorre C (2008) Design, synthesis,
and biological evaluation of pirenzepine analogs bearing a 1,2-
cyclohexanediamine and perhydroquinoxaline units in exchange
for the piperazine ring as antimuscarinics. Bioorg Med Chem
16:7311
Fringuelli R, Schiaffella F, Vecchiarelli A (2001) Antifungal and
immunomodulating activities of 1,4-benzothiazine azole deriv-
atives: review. J Chemother 13:9–14
Fung HB, Kirschenbaum HL, Ojofeitimi BO (2001) Linezolid: an
oxazolidinone antimicrobial agent. Clin Ther 23:356–391
Gupta RR, Kumar M (1988) Synthesis, reactions and properties of
phenothiazines. In: Gupta RR (ed) Phenothiazines and 1,4-
benzothiazines (chemical and biomedical aspects). Elsevier,
Amsterdam, pp 1–161
Gupta RR, Kumar M, Gupta V (1998) Heterocyclic chemistry, vol I.
Springer-Verlag, Germany
Gupta RR, Kumar M, Gupta V (1999) Heterocyclic chemistry, vol II.
Springer-Verlag, Germany
Piestrzeniewicz MK, Wilmanska D, Szemraj J, Studzian K, Gniaz-
dowski M (2004) Interactions of No el morpholine and hexam-
ethylene derivatives of anthracycline antibiotics with DNA. Z
Naturforch 59c:739–748
Rahman A, Choudhary MI, Thomsen WJ (2001) Bioassay techniques
for drug development. Harwood Academic Publishers, The
Netherlands, p 16
Rathore BS, Kumar M (2006) Design and synthesis of 4H-1,
4-benzothiazines containing thiazole ring system for use as
potential biopharmaceuticals. Res Chem Intermed 32:647–651
Rathore BS, Gupta V, Gupta RR, Kumar M (2007) Synthesis of
7-chloro-9-trifluoromethyl-/7-fluorophenothiazines. Heteroatom
Chem 18:81–86
Hermecz I (2003) Recent development in the chemistry of pyrido-
oxazines, pyrido-thiazines, pyrido-diazines and their benzologs:
Part 1. Adv Heterocycl Chem 84:219
Hilfiker MA, Zhang D, Dowdell SE, Neeb MJ (2008) Aminometh-
ylpiperazines as selective urotensin antagonists. Bioorg Med
Chem Lett 18:4470–4473
Hirokawa Y, Kinoshita H, Tanaka T, Nakamura T, Fujimoto K,
Kashimoto S, Kojima T, Kato S (2009) Pleuromutilin derivatives
having a purine ring. Part 2: influence of the central spacer on the
antibacterial activity against gram-positive pathogens. Bioorg
Med Chem Lett 19:170–174
Hussain H, Ahmad VU, Green IR, Krohn K, Hussain J, Badshah A
(2007) Antibacterial organotin(IV) compounds, their synthesis
and spectral characterization. Arkivoc xiv:289–299
Jakubowska J, Lukawska MW, Czyz M (2008) STI571 and morpho-
line derivative of doxorubicin collaborate in inhibition of K562
cell proliferation by inducing differentiation and mitochondrial
pathway of apoptosis. Eur J Pharmacol 596:41–49
Jazayeri S, Moshafi MH, Firoozpour L, Emami S, Rajabalian S, Haddad
M, Pahlavanzadeh F, Esnaashari M, Shafiee A, Foroumadi A
(2009) Synthesis and antibacterial activity of nitroaryl thiadia-
zole–gatifloxacin hybrids. Eur J Med Chem 44:1205–1209
Kanda A, Hashimoto H (1993) Effects of semotiadil fumarate, a novel
calcium antagonist, on blood pressure and heart rate in conscious
spontaneously hypertensive rats. Jpn J pharmacol 63:121–124
Rosato A (2006) Synthesis and antimicrobial activity of 2-(acyl or
carboxyalkyl)-3-(H or alkyl or aryl)-5 (or -6 or -8)-monochloro,
7-fluoro-substituted-4H-1,4-benzothiazines. J Heterocycl Chem
43:1371–1378
Selvakumar N, Reddy BY, Khera MK, Srinivas D, Das J, Trehan S
(2006) Synthesis of novel tricyclic oxazolidinones by a tandem
SN2 and SNAr reaction: SAR studies on conformationally
constrained analogues of linezolid. Bioorg Med Chem Lett
16:4416–4419
Serwar M, Akhtar T, Hameed S, Khan KM (2009) Synthesis, urease
inhibition and antimicrobial activities of some chiral 5-aryl-4-(1-
phenylpropyl)-2H-1,2,4-triazole-3(4H)-thiones. Arkivoc (vii):210–
221
Shami PJ, Saavedra JE, Bonifant CL, Chu J, Udupi V, Malaviya S,
Carr BI, Kar S, Wang M, Keefer LK (2006) Antitumor activity
of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-
1-yl]diazen-1-ium-1, 2-diolate] and related O2-aryl diazeniumdi-
olates in vitro and in vivo. J Med Chem 49:4356–4366
Sharma PK, Ankodia V, Sharma K, Gupta A, Kumar M (2009)
Regioselective one-pot synthesis of 5-chloro-3-methyl-8-triflur-
omethyl-4H-1,4-benzothiazines. Hetrocycl Commun 15:127–
134
123