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Notes and references
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R. Pohl, B. Klepeta´rˇova´, N. P. Ernsting and M. Hocek, J. Org. Chem.,
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20 A typical procedure: synthesis of 6ba. To a solution of 5ba (262 mg,
0.46 mmol) in MeCN (3 mL) was added Pd2(dba)3·CHCl3 (17.3 mg,
0.016 mmol), (2-biphenyl)di-t-butylphosphine(41 mg, 0.14 mmol) and
K2CO3 (200 mg) and the reaction mixture was heated to 120 ◦C for 5 h.
Then it was stirred at rt (usually 18–20 ◦C) overnight. Work-up followed
by column chromatography on silica gel yielded 111 mg (51%) of the
title compound as a yellowish syrup: 1H NMR (600 MHz, C6D6) d 8.57
(s, 1H), 8.08 (dd, J = 30.9, 8.1 Hz, 4H), 7.66 (d, J = 7.6 Hz, 1H), 7.25–
7.18 (m, 3H), 6.97 (d, J = 7.9 Hz, 2H), 6.80 (d, J = 8.0 Hz, 2H), 6.33 (bs,
1H), 5.35 (d, J = 5.7 Hz, 1H), 5.30 (dd, J = 10.4, 5.5 Hz, 1H), 4.54 (dd,
J = 11.6, 5.7 Hz, 1H), 4.43–4.34 (m, 2H), 2.19 (dd, J = 13.5, 5.1 Hz, 1H),
2.13–2.05 (m, 1H), 2.02 (s, 3H), 1.91 (s, 3H); 13C NMR (151 MHz, C6D6)
d 167.27, 166.28, 144.47, 144.27, 138.31, 137.24, 130.50 (2C), 130.45
(2C), 129.84 (2C), 129.82 (2C), 129.40, 128.31, 128.05, 122.63, 121.27,
120.57, 111.88, 100.28, 83.97, 77.58, 76.30, 65.31, 40.44, 21.80, 21.68;
IR (KBr) 3352, 2949, 1715, 1610, 1456, 1271, 1178, 1105, 752 cm-1;
HRMS calcd for C29H27NO5(M + H) 470.1962, found 470.1964.
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