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[18] Representative data of 2: [a]D25 + 4.9 (c 1, CHCl3); 1H NMR (400 MHz, CDCl3): d 1.07 (m, 1H), 1.32 (s, 3H), 1.38 (s, 3H), 1.45 (s, 9H), 1.55
(d, 3H, J = 7.2 Hz), 1.55 (d, 3H, J = 7.2 Hz), 1.68 (m, 2H), 2.26 (dd, 1H, J = 15.2 Hz, 6.4 Hz), 2.40 (dd, 1H, J = 15.2 Hz, 7.2 Hz), 3.59 (sept,
1H, J = 7.2 Hz), 3.71 (m, 1H), 3.84 (m, 1H), 4.09 (m, 1H), 4.17 (m, 1H), 6.88 (s, 1H), 6.99–7.03 (m, 3H), 7.08 (d, 2H, J = 8.0 Hz), 7.18–7.28
(m, 9H); 13C NMR (100 MHz, CDCl3): d 170.1, 164.8, 163.5, 161.0, 141.5, 138.4, 134.7, 133.2, 133.1, 130.5, 128.8, 128.7, 128.3, 128.2, 126.5,
123.5, 121.8, 119.6, 115.4, 115.3, 115.2, 98.7, 80.7, 66.4, 65.9, 42.5, 40.9, 38.1, 36.0, 29.9, 28.1, 26.1, 21.7, 21.5, 19.6; ESI-MS m/z: 655.4
[M+H]+; HR-MS 655.3575 ([M+H]+, C40H47FN2O5; calcd. 655.3547);
Compound 5a(cis): 1H NMR (400 MHz, CDCl3): d 0.85–0.91 (m, 1H), 1.26 (s, 3H), 1.38 (s, 3H), 1.44 (s, 9H), 1.46 (d, 3H, J = 6.4 Hz), 1.46 (d,
3H, J = 6.4 Hz), 1.47 (m, 2H), 2.39 (dd, 1H, J = 15.2 Hz, 6.4 Hz), 2.43 (dd, 1H, J = 15.2 Hz, 7.2 Hz), 3.63 (sept, 1H, J = 7.2 Hz), 4.22 (m, 1H),
4.35 (m, 1H), 5.57 (t, 1H, J = 8.0 Hz), 6.62 (d, 1H, J = 7.6 Hz), 6.88–6.93 (m, 3H), 6.96–7.00 (m, 1H), 7.04–7.08 (m, 4H), 7.16–7.25 (m, 6H);
13C NMR (100 MHz, CDCl3): d 169.9, 164.1, 163.0, 160.6, 138.5, 138.3, 134.4, 132.7, 132.6, 131.3, 130.9, 129.3, 129.1, 128.7, 127.9, 127.5,
127.4, 127.2, 123.6, 123.3, 121.6, 119.9, 115.8, 115.7, 115.5, 115.1, 98.9, 80.7, 65.5, 42.4, 34.5, 32.0, 29.5, 28.1, 26.8, 26.0, 22.7, 22.4, 21.1,
19.6; ESI-MS m/z: 653.1 [M+H]+; HR-MS 653.3367 ([M+H]+, C40H45FN2O5; calcd. 653.3391);
Compound 5b(trans): 1H NMR (400 MHz, CDCl3): d 0.87 (m, 1H), 1.26 (s, 3H), 1.38 (s, 3H), 1.44 (s, 9H), 1.46 (d, 3H, J = 6.4 Hz), 1.46 (d, 3H,
J = 6.4 Hz), 1.47 (m, 2H), 2.39 (dd, 1H, J = 15.2 Hz, 6.4 Hz), 2.43 (dd, 1H, J = 15.2 Hz, 7.2 Hz), 3.82 (sept, 1H, J = 7.2 Hz), 4.22 (m, 1H), 4.35
(m, 1H), 5.19 (dd, 1H, J = 14.0 Hz, 5.6 Hz), 6.77 (d, 1H, J = 14.0 Hz), 6.88–6.93 (m, 3H), 6.96–7.00 (m, 1H), 7.04 À 7.08 (m, 4 Hz), 7.16–7.25
(m, 6H); 13C NMR (100 MHz, CDCl3): d 169.0, 163.2, 162.1, 159.6, 141.6, 137.3, 133.4, 132.3, 132.2, 131.1, 129.7, 127.9, 127.8, 127.7, 127.4,
127.0, 126.9, 126.0, 123.8, 122.6, 121.1, 118.5, 114.8, 114.0, 113.8, 97.9, 79.7, 66.2, 64.8, 41.4, 35.3, 30.9, 28.9, 28.7, 27.1, 25.1, 21.7, 20.4,
20.3, 18.7; ESI-MS m/z: 653.1 [M+H]+; HR-MS 653.3367 ([M+H]+, C40H45FN2O5; calcd. 653.3391);
Compound 6: 1H NMR (400 MHz, CDCl3): d 1.27 (t, 3H, J = 7.2 Hz), 1.27 (t, 3H, J = 7.2 Hz), 1.55 (d, 6H, J = 7.2 Hz), 3.46 (sept, 1H,
J = 7.2 Hz), 3.95–4.07 (m, 4H), 4.25 (d, 2H, J = 10.8 Hz), 6.90 (s, 1H), 6.97–7.01 (m, 3H), 7.07–7.10 (d, 2H, J = 8 Hz), 7.16 À 7.20 (m, 7H),
7.31–7.34 (m, 2H); 13C NMR (100 MHz, CDCl3): d 164.7, 163.7, 161.3, 141.7, 138.3, 134.4, 134.0, 133.9, 130.3, 129.2, 128.7, 128.4, 127.7,
127.6, 126.7, 123.7, 122.6, 119.8, 116.4, 115.4, 115.1, 62.7, 62.6, 42.3, 40.7, 26.6, 21.4, 16.4, 16.3; ESI-MS m/z: 549.1 [M+H]+; HR-MS
548.2295 ([M]+, C31H34FNO4P; calcd. 548.2240).