Journal of Organic Chemistry p. 2558 - 2569 (2017)
Update date:2022-08-04
Topics:
Vacala, Taylor
Bejcek, Lauren P.
Williams, Chloé G.
Williamson, Alexandra C.
Vadola, Paul A.
A mild method for the synthesis of 2-quinolinones via hydroarylation of N-aryl alkynamides is reported. While traditional methods have relied on the use of strong Br?nsted or Lewis acids, this report describes the development of mild reaction conditions that yield 2-quinolinones in good to excellent yield using a commercially available gold catalyst. Substrates bearing a variety of functional groups are presented, with N-substitution proving to be key to the reactivity of several substrates.
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