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COMMUNICATION
of the reaction that can be used in networks. The ability to
engineer different hierarchical relationships among the compo-
nents of the network can lead to a nonlinear response, as was
illustrated with a system that was tuned on then off in response to
increasing levels of input.
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’ ASSOCIATED CONTENT
S
Supporting Information. Synthesis, experimental details,
b
characterization, and sequences of all PNAs used. This material is
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’ AUTHOR INFORMATION
Corresponding Author
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Ghadiri, M. R. J. Am. Chem. Soc. 2003, 125, 346.
(17) Frezza, B. M.; Cockroft, S. L.; Ghadiri, M. R. J. Am. Chem. Soc.
2007, 129, 14875.
’ ACKNOWLEDGMENT
This work was supported by a grant from the European
Research Council (ERC 201749). The Institut Universitaire de
France (IUF) and Boehringer Ingelheim Fonds (fellowship to
K.G.) are gratefully acknowledged.
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