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19. Spectral data for compound 21: 1H NMR (CD3OD, 400 MHz): d 8.79 (d, J = 1.2 Hz,
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83.21, 79.03, 72.28, 59.85, 19.07. LC/MS (m/z), calcd for C13H17N8O4 (M++H),
349.13; found, 349.16.
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1H), 4.17 (d, J = 9.2 Hz, 1H), 4.00 (m, 1H), 3.97 (d, J = 2.0 Hz, 1H), 3.81 (dd,
J = 2.8 Hz, J = 12.4 Hz, 1H), 2.56 (s, 3H), 0.92 (s, 3H). LC/MS (m/z), calcd for
C
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29. The assay was performed by combining 140
concentration) and 0.01 units of adenosine deaminase (Sigma catalog
A5043) in 50 mM potassium phosphate (pH 7.4). Compounds were tested at
10 M. Absorbance @ 265 nm was measured over 4 min and the slope was
lM of adenosine (final
12. Spectral data for compound 9: 1H NMR (CD3OD, 400 MHz): d 8.63 (s, 1H), 6.04 (s,
1H), 4.27 (m, 4H), 4.18 (d, J = 9.2 Hz, 1H), 3.97 (m, 2H), 3.81 (dd, J = 3.2 Hz,
J = 12.8 Hz, 1H), 1.33 (t, J = 7.2 Hz, 6H), 0.94 (s, 3H). 13C NMR (CD3OD,
#
l
400 MHz):
d 158.97, 152.61, 149.80, 147.58, 141.32, 89.56, 81.47, 77.54,
observed. Changes in the slope by incubation with compound versus no
compound indicate inhibition as the slope approaches zero.
70.59, 62.46, 58.15, 17.45, 13.91. LC/MS (m/z), calcd for C15H25N5O7P (M++H),
418.14; found, 418.33.
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´
´
´
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