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Z.-P. LI ET AL.
FIG. 4. Molecular packing diagram of the complex.
dida albicans. It is obvious that the antifungal activities of the
oxovanadium(V) complex are much stronger than those of the
hydrazine ligand. Such increased activity of the metal com-
plexes can be explained on the basis of chelation theory.[19] On
chelation, the polarity of the metal ion will be reduced to a
great extent due to the overlap of the ligand orbital. Further-
more, it increases the delocalization of π-electrons over the
whole chelate ring and enhances the lipophilicity of the com-
plexes.[20] This increased lipophilicity leads to breakdown of the
permeability barrier of the cell and thus retards the normal cell
processes.[21]
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