Journal of Organic Chemistry p. 10088 - 10105 (2013)
Update date:2022-08-15
Topics:
Fer, Mickael J.
Olatunji, Samir
Bouhss, Ahmed
Calvet-Vitale, Sandrine
Gravier-Pelletier, Christine
A straightforward strategy for the synthesis of triazole-containing MraY inhibitors has been developed. It involves the sequential introduction of a terminal alkyne at the 5′ position of an uridine derivative and O-glycosylation with a protected aminoribose leading to an elaborated alkyne scaffold. An efficient Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) allowed the introduction of chemical diversity toward a small library of inhibitors.
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