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Catalysis Science & Technology
Page 5 of 5
DOI: 10.1039/C5CY01299F
Journal Name
COMMUNICATION
Bruneau, P. H. Dixneuf, Chem. Rev. 2012, 112, 5879. (i) A. Deb, S.
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In conclusion, we have reported a mild and regioselective
nickel-catalyzed direct alkynylation of C(sp2)-H bonds of
amides using commercially available, inexpensive 8-
aminoquinoline as a removable bidentate directing group.
Diverse halide substituted benzamides were selectively
alkynylated under our conditions where as synthesis of such
compounds using the traditional approach, “Sonogashira
coupling” is very difficult and rather scare. The present ortho-
alkynylation has a broad substrate scope as well as functional
7
8
For selected reviews (and references cited there in), see: (a) G.
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9
group tolerance, and can be scaled up
.
10 J. He, M. Wasa, K. S. L. Chan, J.ꢀQ. Yu, J. Am. Chem. Soc. 2013, 135
,
This research is supported by the SERB (SB/FT/CS-065/2013)
and CSIR-NCL (MLP028726). V. G. Landge, M. K. Sahoo, and S.
P. Midya thank to CSIR and G. Jaiswal thanks to UGC for
fellowship. We kindly acknowledge Ms. Ahalya P. Murali for
her contribution to this project. We also thank Dr. S. P. Borikar
for GC and GC-MS analysis (Organic Chemistry Division, CSIR-
NCL) and Dr. P. R. Rajamohanan for NMR facility.
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