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Acknowledgements
G.C.M. acknowledges financial support from the Fidelity Biosciences Research Initiative,
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Author contributions
G.C.M. and T.K. conceived and directed the project. C.A. and M.S. contributed equally
to the execution of this work. C.A. prepared acid 1 and conducted all solution-phase
chemistry. M.S. and C.A. conducted all solid-phase experiments, library synthesis,
decoding experiments and biochemical evaluation of the hits. M.S. purified the p53–DBD,
which was cloned and expressed by K.M., and conducted the biochemical characterization
of the hit. M.C. developed the ETD-based method for compound decoding. G.C.M. and
T.K. wrote the manuscript.
Additional information
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