Tetrahedron p. 3947 - 3958 (1991)
Update date:2022-08-04
Topics:
Willisch, Hans
Hiller, Wolfgang
Hemmasi, Bahram
Bayer, Ernst
Propargylglycine, as a powerful inhibitor of microbial growth, was built into a protected tripeptide with the sequence Pro-Pra-Gly. The peptide was employed to study its effects on the activity of prolyl 4-hydroxylase and the collagen biosynthesis. The Boc-protected tripeptide methylester was identified by mass spectrometry and NMR spectroscopy and its crystal structure was established by X-ray diffraction analysis.
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