Journal of Organic Chemistry p. 5610 - 5614 (1991)
Update date:2022-07-30
Topics:
Strekowski, Lucjan
Wydra, Roman L.
Janda, Lubomir
Harden, Donald B.
4,5-Dimethyl- and 4,5,6-trimethyl-substituted pyrimidines are brominated at C5-Me with NBS in CCl4 and at C4(6)-Me with bromine in acetic acid to give the corresponding bromomethyl derivatives in a high yield.The remaining methyl group(s) can also be brominated with high regioselectivity.The 2-methylthio substituent is not oxidized under these conditions.
View MoreSuzhou BEC Fine Chemicals Co., Ltd.
website:http://www.bek.com.cn
Contact:0512-68095917 18913193865
Address:6, Jin Shan Road, Suzhou New District, 215011 China Suzhou Nations Pharmaceutical Innovation Center Inside
Shifang Taifeng New Flame Retardant Co., Ltd
Contact:02884721008
Address:tingjiang industrial park, hefeng town
Contact:0512-63006287
Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
website:http://www.sigmaaldrich.com
Contact:800 558-9160
Address:Industriestrasse 25CH-9471 Buchs SGSwitzerland
Lanzhou huibang biological chemical technology Co., LTD
Contact:0931-7843964
Address:NO.2011,Yannan Road,Chengguan,
Doi:10.1002/cbic.201800170
(2018)Doi:10.1021/ja209335z
(2012)Doi:10.1039/c9nj02672j
(2019)Doi:10.1002/ejoc.201101364
(2012)Doi:10.1002/ejoc.201101028
(2012)Doi:10.1016/j.bmcl.2011.12.021
(2012)