Tetrahedron p. 12069 - 12082 (1995)
Update date:2022-07-29
Topics:
Will, David W.
Breipohl, Gerhard
Langner, Dietrich
Knolle, Jochen
Uhlmann, Eugen
The preparation of novel monomethoxytrityl (Mmt) protected monomers for the synthesis of polyamide nucleic acids (PNAs) is described. The use of base-labile acyl-type nucleobase protecting groups and of a succinyl-linked solid-support offers a synthetic strategy to standard oligonucleotide synthesis conditions. This strategy has been successfully applied for the synthesis of PNAs of mixed base sequence.
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