Organic Letters
Letter
analogy. Currently, one limitation of the reaction is that it is
not applicable to the aliphatic allylic alcohol because of the
very low yield (3x).
As shown in Scheme 3, we also briefly examined ethyl
nitroacetate and acetylacetone as nucleophiles. For the former,
bridge Crystallographic Data Centre, 12 Union Road,
Cambridge CB2 1EZ, UK; fax: +44 1223 336033.
AUTHOR INFORMATION
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Corresponding Authors
a b c d
, , ,
Scheme 3. Allylation with Ethyl Nitroacetate
ORCID
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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We thank the Key Research Program of the Frontier Sciences
of the CAS (Grant No. QYZDB-SSW-SMC026), the NSFC
(21672224, 21472200), and the Government of Yunnan
Province (2017FA002) for financial support.
REFERENCES
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in the presence or absence of substitutes on the phenyl ring,
either of an electron-withdrawing group (5b and 5c) or an
electron-donating group (5d), the reactions took place
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In conclusion, we have disclosed an iridium-catalyzed
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malonates which do not have to be activated beforehand is a
salient feature. The application of this methodology to total
synthesis is ongoing.
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ASSOCIATED CONTENT
* Supporting Information
The Supporting Information is available free of charge on the
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Full characterization, analysis of enantioselectivity,
spectral data, and experimental procedures (PDF)
Accession Codes
CCDC 1882503 contains the supplementary crystallographic
data for this paper. These data can be obtained free of charge
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Ed. 2004, 43, 4595. (b) Streiff, S.; Welter, C.; Schelwies, M.;
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