Chemical and Pharmaceutical Bulletin p. 1446 - 1454 (1991)
Update date:2022-08-03
Topics:
Sawada
Okajima
Aiyama
Nokata
Furuta
Yokokura
Sugino
Yamaguchi
Miyasaka
Novel 36 derivatives (6), bonding the phenolic hydroxyl group of 7-ethyl-10-hydroxycamptothecin (4) with diamines through a monocarbamate linkage, were synthesized and their antitumor activity was evaluated in vivo. The derivatives were soluble in water as their HCl salts with the E lactone ring intact and exhibited significant antitumor activity. One of the derivatives, 6-27 showed excellent activity against L1210 leukemia and other murine tumors. The structure of its hydrochloride trihydrate (CPT-11) was determined by spectroscopic and crystallographic methods.
View MoreCHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD
website:http://www.czyys.com
Contact:0086-519-88802789
Address:No.300,Yanling Middle Road, Changzhou, Jiangsu, China
Qingdao Pana-Life Biochem Co.,Ltd.
Contact:86-532-87683902
Address:No.967 Dalao Road, Licang Zone, Qingdao City,Shandong, China 266021
Shandong LuZhou Amino Acid Co., Ltd
Contact:86-539-2218025
Address:yishui economic and technical development zone zhenxing south road
Nanjing Ruizhi Industry & Technologh Co.,Ltd.
Contact:+86-25-86808110
Address:441-4-A5,NO.12 Longzang Avenue,Yuhuatai District,210039,Nanjing
Contact:+86-512-69561895
Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China
Doi:10.1021/jo972285c
(1998)Doi:10.1007/BF02988706
(1881)Doi:10.1081/SIM-100002048
(2001)Doi:10.1002/ardp.19943270204
(1994)Doi:10.1021/ja0157346
(2001)Doi:10.1080/10473289.2002.10470841
(1932)