References and notes1
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14. General procedure for the preparation of 2-methylbenzofurans 2: A pre-dried screw-capped tube was charged with
1 (1 mmol, 1 eq), Pd(dppf)Cl2 (0.1 mmol, 0.1 eq) and Et3N (2 mmol, 2 eq) in MeCN (5 mL) under N2 atmosphere.
The reaction mixture was heated to 82℃ under stirring for 24 hours. The mixture was concentrated in vacuo and
purified by column chromatography (100% petroleum ether) to afford the pure products.
Pd-Catalyzed Intramolecular Heck Reaction for the Synthesis of
2-Methylbenzofurans
Lixin Zhou, Yuxing Shi, Xueyan Zhu*, Peng Zhang*
State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of
Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, China
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