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for C35H46Cl2N8O6S: 776.3. Found:777.2 [M+H]+. HPLC purity: sys-
tem B, tR 5.38 min.
MS m/z Calcd for C35H45Cl2N5O6S: 733.2. Found: 734.2 [M+H]+.
HPLC purity: system B, tR 5.64 min.
5.1.4. [2-(4-{4-[2,4-Dichloro-3-(2,4-dimethyl-quinolin-8-ylox
ymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbo
nyl}-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluo
roacetate salt (14)
5.1.10. N-{4-[4-(5-Amino-pentanoyl)-piperazine-1-carbonyl]-
tetrahydro-pyran-4-yl}-2,4-dichloro-3-(2,4-dimethyl-quinolin-
8-yloxymethyl)-benzenesulfonamide trifluoroacetate salt (20)
1H NMR (400 MHz, DMSO-d6) d (ppm): 8.50 (1H, s), 8.00 (1H, d),
7.75 (2H, m), 7.60 (1H, m), 7.45 (1H, m), 5.70 (2H, m), 3.70 (8H, br
m), 3.45 (4H, m), 3.35 (2H, m), 2.85 (2H, m), 2.70 (3H, s), 3.65 (3H,
s), 2.40 (2H, m), 2.00 (2H, m), 1.70 (2H, m), 1.60 (4H, m). MS m/z
Calcd for C33H41Cl2N5O6S: 705.2. Found: 706.2 [M+H]+. HPLC pur-
ity: system B, tR 5.60 min.
1H NMR (400 MHz, DMSO-d6) d (ppm): 8.45 (1H, s), 8.05 (1H, d),
7.80 (2H, m), 7.60 (1H, m), 7.45 (2H, m), 5.70 (2H, br s), 4.50 (2H, s),
4.10 (3H, m), 3.80 (4H, m), 3.60 (2H, m), 3.50 (2H, m), 3.40 (3H, m),
3.30 (9H, s), 2.75 (3H, s), 3.70 (9H, s), 2.00 (2H, m), 1.75 (2H, m). MS
m/z Calcd for C33H42Cl2N5O6S: 706.2. Found: 706.4 [M]+. HPLC pur-
ity: system B, tR 5.71 min.
5.1.11. 2,4-Dichloro-N-{4-[4-((S)-2,5-diamino-pentanoyl)-
piperazine-1-carbonyl]-tetrahydro-pyran-4-yl}-3-(2,4-dime
thyl-quinolin-8-yloxymethyl)-benzenesulfonamide trifluoro
acetate salt (21)
5.1.5. [4-(4-{4-[2,4-Dichloro-3-(2,4-dimethyl-quinolin-8-yloxy
methyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-
piperazin-1-yl)-4-oxo-butyl]-trimethyl-ammonium trifluoroa
cetate salt (15)
1H NMR (400 MHz, DMSO-d6) d (ppm): 8.55 (1H, s), 8.1 (3H, br
s), 8.00 (1H, s), 7.75 (3H, br s), 7.70 (2H, m), 7.50 (1H, m), 7.35 (2H,
m), 5.70 (2H, s), 4.50 (1H, s), 3.80–3.35 (12H, vbrm), 2.85 (2H, br s),
2.70 (3H, s), 2.65 (3H, s), 2.00(2H, m),1.70 (6H, m). MS m/z Calcd
for C33H42Cl2N6O6S: 720.23. Found: 721.2 [M+H]+. HPLC purity:
system B, tR 5.20 min.
1H NMR (400 MHz, DMSO-d6) d (ppm): 8.65 (1H, s), 8.05 (1H, d),
7.80 (4H, m), 7.60 (2H, m), 7.50 (2H, m), 5.70 (2H, br s), 3.80 (3H,
m), 3.60 (4H, m), 3.45 (3H, m), 3.30 (4H, m), 3.05 (9H, s), 7.75
(3H, s), 2.70 (3H, s), 2.50 (2H, m), 2.00 (4H, m), 1.70 (2H, m). MS
m/z Calcd for C35H46Cl2N5O6S: 734.2. Found: 734.2 [M]+. HPLC pur-
ity: system B, tR 5.69 min.
5.1.12. [(S)-5-Amino-6-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-
quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-
pyran-4-carbonyl}-piperazin-1-y)-6-oxo-hexyl]-trimethyl-
ammonium trifluoroacetate salt (22)
5.1.6. [5-(4-{4-[2,4-Dichloro-3-(2,4-dimethyl-quinolin-8-ylox
ymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbo
nyl}-piperazin-1-yl)-5-oxo-pentyl]-trimethyl-ammonium triflu
oroacetate salt (16)
1H NMR (400 MHz, DMSO-d6) d (ppm): 8.50 (1H, s), 8.05 (3H, br
s), 8.00 (1H, d), 7.75 (2H, m), 7.70 (3H, m), 7.50 (1H, m), 7.35 (2H,
m), 5.70 (2H,s), 4.40 (2H, br s), 3.95–3.30 (12H, m), 2.85(2H, m),
2.75 (3H, s), 3.70 (3H, s), 2.00 (2H, m), 2.75 (4H, m), 1.60 (2H,
m), 1.45 (2H, m). MS m/z Calcd for C34H44Cl2N6O6S: 734.2. Found:
735.6 [M+H]+. HPLC purity: system B, tR 5.20 min.
1H NMR (400 MHz, DMSO-d6) d (ppm): 8.85 (1H, s), 8.15 (1H, d),
7.70 (5H, m), 5.70 (2H, br s), 4.45–3.40 (7H, m), 3.40–3.20 (7H, m),
3.10 (9H, s), 2.80 (6H, br s), 2.50 (2H, m), 1.95 (2H, m), 1.70 (2H, m),
1.55 (2H, m). MS m/z Calcd for C36H48Cl2N5O6S: 748.3. Found:
748.2 [M]+. HPLC purity: system B, tR 5.65 min.
5.1.7. [6-(4-{4-[2,4-Dichloro-3-(2,4-dimethyl-quinolin-8-
yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-
carbonyl}-piperazin-1-yl)-6-oxo-hexyl]-trimethyl-ammonium
trifluoroacetate salt (17)
5.1.13. N-{4-[4-((S)-2-Amino-5-dimethylamino-pentanoyl)-
piperazine-1-carbonyl]-tetrahydro-pyran-4-yl}-2,4-dichloro-3-
(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonamide
trifluoroacetate salt (23)
1H NMR (400 MHz, DMSO-d6) d (ppm): 8.80 (1H, s), 8.05 (1H, d),
7.80 (5H, m), 5.70 (2H, br s), 3.80 (7H, vbr m), 3.35 (7H, m), 3.00
(9H, s), 2.80 (6H, br s), 2.40 (2H, m), 1.95 (2H, m), 1.70 (2H, m),
1.50 (2H, m), 1.30 (2H, m). MS m/z Calcd for C37H50Cl2N5O6S:
762.3. Found: 762.3 [M]+. HPLC purity: system B, tR 5.77 min.
1H NMR (400 MHz, DMSO-d6) d (ppm): 9.70 (1H, br s), 8.60 (1H,
s), 8.20 (3H, br s), 8.00 (1H, d), 7.80 (2H, m), 7.60 (1H, m), 7.50 (2H,
m), 5.70 (2H, s), 3.90–3.50 (8H, m), 3.45 (2H, m), 3.30 (2H, m), 3.10
(2H,m), 2.80 (6H, s), 2.70 (3H, s), 2.65 (3H, s), 1.95 (2H, m), 1.70
(6H, m). MS m/z Calcd for C35H46Cl2N6O6S: 748.3. Found: 749.4
[M+H]+. HPLC purity: system B, tR 5.42 min.
5.1.8. [7-(4-{4-[2,4-Dichloro-3-(2,4-dimetyl-[7-(4-{4-[2,4-
Dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzene
sulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperazin-1-yl)-
7-oxo-heptyl]-trimethyl-ammonium trifluoroacetate salt (18)
1H NMR (400 MHz, DMSO-d6) d (ppm): 8.80 (1H, s), 8.00 (1H, d),
7.80 (1H, d), 7.00 (4H, m), 5.70 (2H, br s), 3.80 (3H, m), 3.70 (4H,
m), 3.50 (3H, m), 3.30 (4H, m), 3.00 (9H, s), 2.80 (6H, br s), 2.40
(2H, m), 1.90 (2H, m), 1.70 (4H, m), 1.55 (2H, m), 1.30 (4H, m).
MS m/z Calcd for C38H52Cl2N5O6S: 776.3. Found: 776.3 [M]+. HPLC
purity: system B, tR 5.77 min.
5.1.14. N-{4-[4-((S)-2-Amino-6-dimethylamino-hexanoyl)-
piperazine-1-carbonyl]-tetrahydro-pyran-4-yl}-2,4-dichloro-3-
(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonamide
trifluoroacetate salt (24)
1H NMR (400 MHz, DMSO-d6) d (ppm): 9.70 (1H, br s), 8.85 (1H,
s), 8.20 (3H, br s), 8.00 (1H, d), 7.90-7.50 (5H, m), 5.70 (2H, br s),
4.50 (1H, br s), 4.00–3.15 (18H, m), 3.00 (2H, m), 2.75 (6H, br s),
1.90 (2H, m), 1.60 (6H, m), 1.30 (2H, m). MS m/z Calcd for
C
36H48Cl2N6O6S: 762.3. Found: 763.3 [M+H]+. HPLC purity: system
B, tR 5.28 min.
5.1.9. 2,4-Dichloro-N-{4-[4-(5-dimethylamino-pentanoyl)-
piperazine-1-carbonyl]-tetrahydro-pyran-4-yl}-3-(2,4-
dimethyl-quinolin-8-yloxymethyl)-benzenesulfonamide
trifluoroacetate salt (19)
5.1.15. (S)-5-Amino-6-(4-(4-(2,4-dichloro-3-((2,4-dimethyl
quinolin-8-yloxy)methyl)phenylsulfonamido)tetrahydro-2H-
pyran-4-carbonyl)piperazin-1-yl)-N,N,N-trimethyl-6-oxohexan-
1-aminium trifluoroacetate salt (25)
1H NMR (400 MHz, DMSO-d6) d (ppm): 9.10(1H, br s), 8.45 (1H,
s), 8.00(1H, d), 7.75 (2H, m), 7.50 (1H, m), 7.35 (2H, m), 5.70 (2H, s),
3.75 (4H, m), 3.60 (4H, m), 3.40 (4H, m), 2.80 (6H, s), 2.75 (3H, s),
2.70 (3H, s), 2.45 (2H, m), 2.00 (2H, m), 1.70 (4H, m), 1.35 (2H, m).
1H NMR (400 MHz, DMSO-d6) d (ppm): 8.80 (1H, s), 8.20 (3H, s),
8.00 (1H, d), br7.80 (2H, m), 7.60 (1H, m), 7.50 (2H, m), 5.70 (2H, br
s), 4.45 (1H, m), 4.00–3.20 (14H, m), 3.00 (9H, s), 2.70 (3H, s), 2.65