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hazardous bromine vapor during the reaction; (d) the total elim-
ination of the use of toxic organic solvents; (e) a simple experi-
mental procedure; (g) an easy work-up; (h) excellent selectivity
in case of activated coumarins and (i) good control over the
outcome of the reaction by varying the amount of reagent. The
aforesaid protocol thus provides an improved procedure for the
synthesis of useful bromocoumarins having important pharma-
ceutical, agricultural and other physicochemical properties.
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Supporting Information
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Supporting Information File 1
General experimental procedure for the preparation of DD
and solvent-free bromination of substituted coumarins
using DD along with the spectral data of the products.
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Acknowledgements
The authors express sincere thanks to Mr. N. Dutta of the Indian
Association for the Cultivation of Science and Mr. J. Podder of
Jadavpur University for their invaluable assistance and support
in the course of this investigation. Financial and infrastructural
support from CSIR (Grant No. 01(2383)/10/EMR-II), DST-
PURSE Program, UGC-CAS Program and DST-FIST Program
at Jadavpur University are also gratefully acknowledged.
License and Terms
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