2854
D. Bahulayan, S. Arun / Tetrahedron Letters 53 (2012) 2850–2855
Table 4
List of acyclic peptidotriazoles prepared
O
O
Br
O
NH
O
N
N
O
Br
Br
NH
O
HN
O
N
NH
O
Br
10
(7a +9)
O
N
96%
log P = 4.40
O
N
N
12
( 7c +9)
log P = 4.36
94%
O
Br
O
N
Br
O
NH
O
O
O
Br
Br
NH
NH
O
HN
O
O
N N
11 ( 7b+9)
NH
Br
O
O
98%
log P= 5.21
N
O
Cl
O
N
Br
N
N
13 ( 7d+9)
Cl
Br
95%
log P = 5.03
Br
O
HN
N N
O
14 ( 7e +9)
log P = 5.08
O
90%
Cl
Br
O
Br
O
O
O
N
N
N N
Br
Br
NH
NH
O
NH
O
O
NH
O
N
N
16 ( 7g +9)
O
94%
log P = 5.03
15 ( 7f +9)
log P = 5.16
98%
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In conclusion, we have demonstrated a two-step synthesis of
cyclic as well as acyclic peptidomimetics based on an MCR and
click strategy. Structural features as well as the preliminary assess-
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Supplementary data
Supplementary data associated with this article can be found, in
15. Multicomponent Reactions: Zhu, J., Bienayme, H., Eds.; Wiley-VCH: Weinheim,
2005.
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