Synthetic Communications p. 1876 - 1886 (2015)
Update date:2022-07-30
Topics:
Jangale, Asha D.
Wagh, Yogesh B.
Tayade, Yogesh A.
Dalal, Dipak S.
A concise approach for the transformation of various S-amino acids into the 5-alkyl-3-phenyl-2-thioxoimidazolidin-4-one heterocycles using phenylisothiocyanate is described. Phenylthiohydantoins of amino acid were synthesized at room temperature in Et3N/DMF-H2O with easy workup and excellent yields.
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