Journal of the American Chemical Society p. 1456 - 1462 (1992)
Update date:2022-09-26
Topics:
Steliou, Kosta
Salama, Paul
Yu, Xiaoping
A detailed study into the design and synthesis of stable 1,2-dithietane derivatives for the generation of diatomic sulfur (S2) was undertaken. Computer-aided evaluation of enthalpic differences was used to direct the synthesis of target compounds and, although all of the compounds calculated to afford S2 that were prepared did yield diatomic sulfur, an isolable 1,2-dithietane other than dithiatopazine failed to materialize. The results of this study provide convincing evidence that the computational procedure outlined can be successfully used to predict the course of S2 extrusion pathways from potential dithionocarbonylated derivatives. To determine if the disulfide moiety found in the Diels-Alder adduct derived from the addition of diatomic sulfur to conjugated 1,3-dienes is due to a transference mechanism involving the transient 1,2-dithietane intermediate, a chiral nonracemic binaphthyl source of S2 was prepared. Reactions of S2 from this source with chiral nonracemic and prochiral conjugated 1,3-dienes indicate that the added disulfide moiety would be inconsistent with a transference mechanism and that a "free" acting S2 unit is more likely to be involved.
View MoreDaqing E-shine Chemical Co.,LTD
Contact:0086-024-31285112
Address:Hongweiyuan area, Ranghulu district
Hangzhou Yanshan Chemical Co.,Ltd.
Contact:86-571- 87698076
Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
Shandong Dayi Chemical Co., Ltd.
website:http://www.dayi.com.cn
Contact:+86- 535-7388728. 15306386031
Address:No 1 Danya west road, Laiyang City, Shandong province
Wuhan Sun-shine Bio-technology Corporation Limited
Contact:+862765522452
Address:武汉市东湖高新区高新二路388号生物医药加速器16栋501
Nanyang Tianhua pharmaceutical Co.,Ltd.
Contact:+8618639816203
Address:Longsheng Industrial Park
Doi:10.1016/j.carres.2012.07.012
(2012)Doi:10.1021/acs.orglett.1c00222
(2021)Doi:10.1080/10610278.2012.688122
(2012)Doi:10.1016/j.mencom.2015.07.030
(2015)Doi:10.1021/jo4020112
(2013)Doi:10.1039/c19670000296
(1967)