10.1002/anie.201711359
Angewandte Chemie International Edition
COMMUNICATION
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dehydrogenative [4+2] annulation of aromatic ketimine
derivatives with styrenes. This methodology provided an powerful
synthetic tool for the formation of multi-substituted 3,4-
dihydroisoquinoline derivatives form commercially available
materials. The photo-oxidation of alkene lead the formation of
alkene radical cation, which would achieve the well control of the
regioselectivity. And the excellent trans-diastereoselectivity could
be observed in this radical reaction. The mildness and high atomic
economy of this approach would make it appealing for the further
application into synthesis of important natural products,
pharmaceuticals, and functional materials.
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Acknowledgements
This work was supported by the National Natural Science
Foundation of China (21390400, 21520102003, 21272180,
21302148), the Hubei Province Natural Science Foundation of
China (2013CFA081), the Research Fund for the Doctoral
Program of Higher Education of China (20120141130002), and
the Ministry of Science and Technology of China
(2012YQ120060). The Program of Introducing Talents of
Discipline to Universities of China (111 Program) is also
appreciated.
[8]
Keywords: alkenes · radical cation · annulation · heterocyles ·
synthetic method
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