6646
C. L. Clouser et al. / Bioorg. Med. Chem. Lett. 22 (2012) 6642–6646
Figure 3. Resveratrol and decitabine act synergistically to inhibit HIV-1 infectivity in the absence of cellular toxicity.
7. Loeb, L. A.; Essigmann, J. M.; Kazazi, F.; Zhang, J.; Rose, K. D.; Mullins, J. I. Proc.
Acknowledgments
Nat. Acad. Sci. U.S.A. 1999, 96, 1492.
8. Ruiz-Jarabo, C. M.; Ly, C.; Domingo, E.; de la Torre, J. C. Virology 2003, 308, 37.
9. Smith, R. A.; Loeb, L. A.; Preston, B. D. Virus Res. 2005, 107, 215.
10. Dapp, M. J.; Clouser, C. L.; Patterson, S.; Mansky, L. M. J. Virol. 2009, 83, 11950.
11. Severson, W. E.; Schmaljohn, C. S.; Javadian, A.; Jonsson, C. B. J. Virol. 2003, 77,
481.
12. Contreras, A. M.; Hiasa, Y.; He, W.; Terella, A.; Schmidt, E. V.; Chung, R. T. J.
Virol. 2002, 76, 8505.
13. Cuevas, J. M.; Gonzalez-Candelas, F.; Moya, A.; Sanjuan, R. J. Virol. 2009, 83,
5760.
This research was supported by a University of Minnesota
Academic Health Center Translational Research Grant as well as
by NIH Grant GM56615. C.L.C. was supported in part from NIH Grant
T32 CA09138 (Cancer Biology Training Grant); M.A.B. was sup-
ported in part from NIH Grant T32 GM008700 (Chemistry-Biology
Interface Training Grant).
14. Lutchman, G.; Danehower, S.; Song, B. C.; Liang, T. J.; Hoofnagle, J. H.; Thomson,
M.; Ghany, M. G. Gastroenterology 2007, 132, 1757.
Supplementary data
15. Clouser, C. L.; Patterson, S. E.; Mansky, L. M. J. Virol. 2010, 84, 9301.
16. Sumpter, L. R.; Inayat, M. S.; Yost, E. E.; Duvall, W.; Hagan, E.; Mayhew, C. N.;
Elford, H. L.; Gallicchio, V. S. Antiviral Res. 2004, 62, 111.
17. Lori, F.; Malykh, A.; Cara, A.; Sun, D.; Weinstein, J. N.; Lisziewicz, J.; Gallo, R. C.
Science 1994, 266, 801.
Supplementary data associated with this article can be found, in
18. Davidoff, S.; Shah, R. D.; Arunabh, T. Respir. Med. 2006, 100, 760.
19. Gupta, N.; Ahmed, I.; Steinberg, H.; Patel, D.; Nissel-Horowitz, S.; Mehrotra, B.
Am. J. Clin. Oncol. 2002, 25, 96.
References and notes
20. Lisziewicz, J.; Foli, A.; Wainberg, M.; Lori, F. Drug Saf. 2003, 26, 605.
21. Heredia, A.; Davis, C.; Redfield, R. J. Acquir. Immune Defic. Syndr. 2000, 25,
246.
22. Wang, L. X.; Heredia, A.; Song, H.; Zhang, Z.; Yu, B.; Davis, C.; Redfield, R. J.
Pharm. Sci. 2004, 93, 2448.
1. (UNAIDS), J. U. N. P. o. H. A.; WHO, 2010; Vol. 2010.
2. Hammer, S. M.; Eron, J. J. J.; Reiss, P.; Schooley, R. T.; Thompson, M. A.;
Walmsley, S.; Cahn, P.; Fischl, M. A.; Gatell, J. M.; Hirsch, M. S.; Jacobsen, D. M.;
Montaner, J. S.; Richman, D. D.; Yeni, P. G.; Volberding, P. A. JAMA 2008, 300, 555.
3. Coffin, J. M. Science 1995, 267, 483.
23. Zhang, H. S.; Zhou, Y.; Wu, M. R.; Zhou, H. S.; Xu, F. Life Sci. 2009, 85, 484.
24. Zhang, H. S.; Wu, M. R. Virus Res. 2009, 146, 51.
4. Drake, J. W.; Holland, J. J. Proc. Nat. Acad. Sci. U.S.A. 1999, 96, 13910.
5. Crotty, S.; Andino, R. Microbes Infect. 2002, 4, 1301.
25. Fontecave, M.; Lepoivre, M.; Elleingand, E.; Gerez, C.; Guittet, O. FEBS Lett. 1998,
421, 277.
26. Prichard, M. N.; Shipman, C., Jr. Antiviral Res. 1990, 14, 181.
6. Graci, J. D.; Harki, D. A.; Korneeva, V. S.; Edathil, J. P.; Too, K.; Franco, D.;
Smidansky, E. D.; Paul, A. V.; Peterson, B. R.; Brown, D. M.; Loakes, D.; Cameron,
C. E. J. Virol. 2007, 81, 11256.