Synthesis p. 229 - 234 (1992)
Update date:2022-08-02
Topics:
Denmark
Kim
A large-scale and practical synthesis of (dl)-1,3-diphenyl-1,3-propanediamine (1) has been achieved by a highly diastereoselective phenylcerium dichloride addition to 1-tert-butoxycarbonyl-4,5-dihydro-5-phenylpyrazole (3). Alkylcerium addition reaction to the corresponding 5-alkyl substituted 1-Boc-4,5-dihydropyrazoles was less satisfactory mainly giving ring-cleaved products. Further elaboration of the diamine 1 to the N-substituted derivatives 8a-f bearing N-methyl, N-ethyl, N-isopropyl, N-neopentyl, N-benzyl, and N-mesitylmethyl groups is described.
View MoreChemtrade International ( China )
Contact:+86-532-86893005
Address:Rm 2-501, Huaxia Zonghe Building, No. 410 JInggangshan Road, Huangdao
Shanghai better-in Medical Technology Co.,LTD.
Contact:+86-21-38921049
Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
ZHEJIANG CHEMICAL INDUSTRY INSTITUTE TECHNOLOGY CO.,LTD
Contact:86-575-82730298
Address:shangyu
Contact:0086 533 2282832
Address:Zibo,Shandong
website:http://www.amadischem.com
Contact:86-571-89925085
Address:Watts Cosine.No.166.Xiangmao Road.
Doi:10.1016/0008-6215(92)80040-8
(1992)Doi:10.1021/ol502131r
(2014)Doi:10.1080/15257779508012439
(1995)Doi:10.1080/00397919208020844
(1992)Doi:10.1016/j.molstruc.2021.130669
(2021)Doi:10.1039/DT9920000787
(1992)