Journal of Medicinal Chemistry p. 1511 - 1519 (1993)
Update date:2022-07-30
Topics:
Angelucci, Luciano
Calvisi, Pina
Catini, Roberto
Cosentino, Ugo
Cozzolino, Roberto
et al.
A series of 3-(acylamino)-ε-caprolactams and 3-(acylamino)-2-pyrrolidinones was synthesized.Some of these compounds reversed at different degrees electroconvulsive shock- and Scopolamine-induced amnesia, using a step-through passive avoidance in mice.Classical nootropic drugs, i.e., Aniracetam, Oxiracetam, and Piracetam, were used as reference compounds.Within the analyses of data performed, we introduced a new parameter, the confrontation index (CI), which is a function of Mann-Whitney's U statistic.The CI permits a common scale of activity of substances to be generated, independently of probabilistic hypotheses, with higher scores representing higher activities.The most active compounds were characterized by the formylamino and <3-(trifluoromethyl)benzoyl>amino groups in the 3-position of the ring.None of the substances assayed showed any effect on spontaneous behavior and neurovegetative system.
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