Organic Letters
Letter
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(3). The selective 9-O-methylation wasaccomplished with useof
the orthogonal protecting group strategy employing 14 and
MeOTf. The chemical α(2,3)-sialylation of inositol was
successfully achieved employing the cis-diol acceptor 24 with
an appropriate protecting group pattern. The CJP-series
framework was constructed by phosphodiester bond formation
using the phosphoramidite building block 6. This approach
allows the synthesis of CJP-1 and synthetic CJP analogues with
the possibility of replacement of one or more functionalities for
SAR studies to support potential neurodegenerative therapeutic
applications. The detailed mechanism of action of the
echinodermatous SIPSs will be investigated by our research
group.
́
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ASSOCIATED CONTENT
* Supporting Information
■
S
The Supporting Information is available free of charge on the
Experimental details and procedures, compound charac-
terization data, and copies of 1H, 13C, and 31P spectra for
AUTHOR INFORMATION
Corresponding Authors
■
ORCID
Author Contributions
∥K.G., H.T., and Y.T. contributed equally.
(14) Yamagishi, M.; Hosoda-Yabe, R.; Tamai, H.; Konishi, M.;
Imamura, A.; Ishida, H.; Yabe, T.; Ando, H.; Kiso, M. Mar. Drugs 2015,
13, 7250.
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49, 695. (c) Arao, K.; Inagaki, M.; Miyamoto, T.; Higuchi, R. Chem.
Pharm. Bull. 2004, 52, 1140.
Notes
The authors declare no competing financial interest.
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291.
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ACKNOWLEDGMENTS
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This work was financially supported in part by a JSPS KAKENHI
grant (JP18K05461 to H.-N.T., JP15K07409 to H.I., and
JP15H04495 and JP18H03942 to H.A.) and by JST CREST
Grant (JPMJCR18H2 to H.A.). We gratefully acknowledgment
the support of the World Premier International Research Center
Initiative “the Institute of Integrated Cell-Material Sciences”
(WPI-iCeMS) from MEXT.
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