Journal of Medicinal Chemistry p. 10026 - 10046 (2017)
Update date:2022-08-15
Topics:
Carzaniga, Laura
Amari, Gabriele
Rizzi, Andrea
Capaldi, Carmelida
De Fanti, Renato
Ghidini, Eleonora
Villetti, Gino
Carnini, Chiara
Moretto, Nadia
Facchinetti, Fabrizio
Caruso, Paola
Marchini, Gessica
Battipaglia, Loredana
Patacchini, Riccardo
Cenacchi, Valentina
Volta, Roberta
Amadei, Francesco
Pappani, Alice
Capacchi, Silvia
Bagnacani, Valentina
Delcanale, Maurizio
Puccini, Paola
Catinella, Silvia
Civelli, Maurizio
Armani, Elisabetta
Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacological inhibition has been shown to exert therapeutic efficacy in chronic obstructive pulmonary disease (COPD). Herein, we describe a drug discovery program aiming at the identification of novel classes of potent PDE4 inhibitors suitable for pulmonary administration. Starting from a previous series of benzoic acid esters, we explored the chemical space in the solvent-exposed region of the enzyme catalytic binding pocket. Extensive structural modifications led to the discovery of a number of heterocycloalkyl esters as potent in vitro PDE4 inhibitors. (S?,S??)-18e and (S?,S??)-22e, in particular, exhibited optimal in vitro ADME and pharmacokinetics properties and dose-dependently counteracted acute lung eosinophilia in an experimental animal model. The optimal biological profile as well as the excellent solid-state properties suggest that both compounds have the potential to be effective topical agents for treating respiratory inflammatory diseases.
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