Journal of Medicinal Chemistry p. 9691 - 9702 (2019)
Update date:2022-08-04
Topics:
Feng, Yuting
Park, Jaeok
Li, Shi-Guang
Boutin, Rebecca
Viereck, Peter
Schilling, Matthew A.
Berghuis, Albert M.
Tsantrizos, Youla S.
Thienopyrimidine-based allosteric inhibitors of the human farnesyl pyrophosphate synthase (hFPPS), characterized by a chiral α-aminophosphonic acid moiety, were synthesized as enantiomerically enriched pairs, and their binding mode was investigated by X-ray crystallography. A general consensus in the binding orientation of all (R)- and (S)-enantiomers was revealed. This finding is a prerequisite for establishing a reliable structure-activity relationship (SAR) model.
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(1992)Doi:10.1039/c5ob00085h
(2015)Doi:10.1016/j.tetlet.2012.11.038
(2013)Doi:10.1016/j.tet.2012.11.018
(2013)Doi:10.1055/s-0032-1317347
(2012)Doi:10.1081/NCN-100002429
(2001)