10.1002/adsc.201901573
Advanced Synthesis & Catalysis
To a 4 mL vial equipped with a magnetic stirring bar were
added substrate 1a (28.6 mg, 0.1 mmol, 1 equiv),
Pd(OAc)2 (2.3 mg, 0.01 mmol, 10 mol%), PPh3 (5.9 mg,
0.022 mmol, 22 mol%), Cs2CO3 (65.2 mg, 0.2 mmol, 2
equiv), 4 Å MS (100.0 mg) and 1 mL of toluene under an
argon atmosphere. After the vial was sealed and stirred at
100 oC for 12 h, the reaction was cooled to room
temperature. The mixture was filtered through celite and
washed with EA (20 mL). Then the filtration was
concentrated under reduced pressure. The desired product
2a (15.3 mg) was obtained in 82% yield as a yellow solid
after purification by silica gel chromatography (PE:EA =
100:1).
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Acknowledgements
We thank the NSFC (21772148, 21971198, and 21602160) and
Wuhan University (WHU) for financial support.
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