Journal of Medicinal Chemistry p. 1929 - 1939 (2015)
Update date:2022-08-02
Topics:
Ellis, J. Michael
Altman, Michael D.
Bass, Alan
Butcher, John W.
Byford, Alan J.
Donofrio, Anthony
Galloway, Sheila
Haidle, Andrew M.
Jewell, James
Kelly, Nancy
Leccese, Erica K.
Lee, Sandra
Maddess, Matthew
Miller, J. Richard
Moy, Lily Y.
Osimboni, Ekundayo
Otte, Ryan D.
Reddy, M. Vijay
Spencer, Kerrie
Sun, Binyuan
Vincent, Stella H.
Ward, Gwendolyn J.
Woo, Grace H. C.
Yang, Chiming
Houshyar, Hani
Northrup, Alan B.
Development of a series of highly kinome-selective spleen tyrosine kinase (Syk) inhibitors with favorable druglike properties is described. Early leads were discovered through X-ray crystallographic analysis, and a systematic survey of cores within a selected chemical space focused on ligand binding efficiency. Attenuation of hERG ion channel activity inherent within the initial chemotype was guided through modulation of physicochemical properties including log D, PSA, and pKa. PSA proved most effective for prospective compound design. Further profiling of an advanced compound revealed bacterial mutagenicity in the Ames test using TA97a Salmonella strain, and subsequent study demonstrated that this mutagenicity was pervasive throughout the series. Identification of intercalation as a likely mechanism for the mutagenicity-enabled modification of the core scaffold. Implementation of a DNA binding assay as a prescreen and models in DNA allowed resolution of the mutagenicity risk, affording molecules with favorable potency, selectivity, pharmacokinetic, and off-target profiles.
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