Journal of Medicinal Chemistry p. 3666 - 3679 (2013)
Update date:2022-08-05
Topics:
Disch, Jeremy S.
Evindar, Ghotas
Chiu, Cynthia H.
Blum, Charles A.
Dai, Han
Jin, Lei
Schuman, Eli
Lind, Kenneth E.
Belyanskaya, Svetlana L.
Deng, Jianghe
Coppo, Frank
Aquilani, Leah
Graybill, Todd L.
Cuozzo, John W.
Lavu, Siva
Mao, Cheney
Vlasuk, George P.
Perni, Robert B.
The sirtuins SIRT1, SIRT2, and SIRT3 are NAD+ dependent deacetylases that are considered potential targets for metabolic, inflammatory, oncologic, and neurodegenerative disorders. Encoded library technology (ELT) was used to affinity screen a 1
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