Synthesis p. 587 - 590 (1992)
Update date:2022-08-04
Topics:
Schmid
Bradley
The synthesis of two novel glyceraldehyde surrogates, 2,3-O-(3-pentylidene)-D-glyceraldehyde (2) and 2,3-O-(3-pentylidene)-L-glyceraldehyde (3) is presented. Synthesis, handling and storage advantages of 2 and 3 over the conventionally employed 2,3-O-isopropylidene-D-glyceraldehyde (1) are discussed. The 3-pentanone-derived protecting group facilitates the extraction of product from aqueous oxidation solutions, while the 3-pentanone liberated on ketal deprotection can be efficiently removed at reduced pressures. The synthesis employs a buffered potassium periodate oxidation which offers significant advantages over sodium periodate in glycol cleavage reactions.
View Morewebsite:http://www.debyesci.com
Contact:+85221376140
Address:Rm. 19C, Lockhart Ctr., 301-307 Lockhart Rd., Wan Chai
Contact:Tel:+86-29-88764861 Fax:+86-29-88764861
Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
Contact:+86-28-88523492
Address:714rooms of Time Square, Pujiang County
Zhejiang Kangfeng Chemical Co.,LTD.
Contact:+86-579-86709687
Address:Xueshizhai Industrial Zone, Weishan Town,Dongyang City, Zhejiang Province ,China
website:http://www.finetechnology-ind.com
Contact:86-27-87465837
Address:wuhan
Doi:10.1016/j.tet.2013.03.080
(2013)Doi:10.1021/acs.jmedchem.6b00287
(2016)Doi:10.1039/c2cc33706a
(2013)Doi:10.1021/jm00097a006
(1992)Doi:10.1021/jo400496z
(2013)Doi:10.1039/c9ob01903k
(2019)