Chemistry - A European Journal
10.1002/chem.201602416
COMMUNICATION
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the ThT assay. The CD analyses also revealed that the 2,2'-
diindolylmethanes only induce subtle structural changes as
opposed to the major changes triggered by Phen-DC3 in the
human telomeric and ribosomal DNA G4 structures. Taken
together, it is clear that the developed 2,2'-diindolylmethanes
specifically target defined G4 structures without inducing large
conformational changes and that this selectivity can be fine-
tuned by chemical modifications. The details of the observed
effects by these compounds, with assay conditions closer to
physiological settings, as well as their optimizations and use as
research tools, both in vitro and in vivo, are currently on-going in
our labs.
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Acknowledgements
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This work was supported by the Kempe foundations
(SMK1449). In addition, NS was also supported by Swedish
Society for Medical Research and the Swedish Research
Council and EC was supported by grants from Lion's Cancer
Research Foundation, Umeå University.
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Keywords: G-quadruplex
•
G4 structure
•
2,2'-
Diindolylmethane • Selectivity • Phen-DC3
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