Chemical and Pharmaceutical Bulletin p. 1486 - 1493 (1992)
Update date:2022-08-04
Topics:
Yamanaka
Suda
Kabasawa
Kawamura
Ogawa
Sawada
Ohhara
Structural modification of the cardiotonic agent, loprinone (E-1020, 1), suggested by data that it has a less positive chronotropic effect than milrinone (15), led us to find novel bradycardic agents that were structurally different from homoveratryl amine derivatives. Alkyl-oxy, -thio, and -amino derivatives at the 2-position of the pyridine ring of 1 produced bradycardic activity without a significant effect on blood pressure and myocardial contractility. Aryloxy analogues also decreased beart rate, and members with an electron-withdrawing group at the ortho position of the phenyl ring showed higher activity. Replacement of the imidazo[1,2-a]pyridine with pyridine resulted in diminished activity. The mechanism of bradycardic activity of these compounds seems to be direct action on the sinus node.
View MoreContact:+49-4101-3053-0
Address:Waldhofstrasse 14 ,25474 Ellerbek Germany
Jiangxi Dongxu Chemical Science & Technology Co.,Ltd
Contact:+86-791-86899381
Address:Nanchang, Jiangxi, China
Suzhou SuKaiLu Chemical Technology Co., Ltd.
Contact:+86-512-62766020
Address:Floor 4, Building 1, Xinyi Pharmaceutical Valley Wisdom Industrial Park, 415 Changyang Street, Suzhou Industrial Park, Jiangsu Province
Buffett (China) Holding Co.,Ltd
Contact:4006570891
Address:
Contact:(86) 731 88718666
Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
Doi:10.1021/ol401276b
(2013)Doi:10.1080/00304948.2013.786587
(2013)Doi:10.1016/S0022-1139(98)00310-8
(1999)Doi:10.1021/ja00050a030
(1992)Doi:10.1002/anie.201209109
()Doi:10.1016/S0040-4020(01)88306-X
(1992)