Journal of Organic Chemistry p. 6409 - 6423 (2016)
Update date:2022-08-15
Topics:
Suchand, Basuli
Satyanarayana, Gedu
Recent trends in research have gained an orientation toward developing efficient strategies using innocuous reagents. The earlier reported transition-metal-catalyzed carbonylations involved either toxic carbon monoxide (CO) gas as carbonylating agent or functional-group-assisted ortho sp2 C-H activation (i.e., ortho acylation) or carbonylation by activation of the carbonyl group (i.e., via the formation of enamines). Contradicting these methods, here we describe an environmentally benign process, [Pd]-catalyzed direct carbonylation starting from simple and commercially available iodo arenes and aldehydes, for the synthesis of a wide variety of ketones. Moreover, this method comprises direct coupling of iodoarenes with aldehydes without activation of the carbonyl and also without directing group assistance. Significantly, the strategy was successfully applied to the synthesis n-butylphthalide and pitofenone.
View MoreSuzhou Time-chem Technologies Co., Ltd.
Contact:0512-63983931/68086856
Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
Contact:+86-533-3112891
Address:zibo
Tianjin Te-An Chemtech Co., Ltd.
Contact:+86-22-65378638
Address:A5-8, No.80 Haiyun Street, TEDA
Contact:86-575-86132822,86-575-86085355
Address:No.418 Dadao West Road,Qixing Street,Xinchang, Zhejiang Province, China.
Zhejiang Chemicals Import & Export Corporation (ZHECHEM)
Contact:+86-571-87046953
Address:No. 37, Qingchun Road
Doi:10.1016/j.bmc.2012.06.020
(2013)Doi:10.1016/S0040-4039(00)61198-X
(1992)Doi:10.1016/S0040-4039(00)61246-7
(1992)Doi:10.1002/ejoc.201201034
(2013)Doi:10.1021/acs.orglett.8b03944
(2019)Doi:10.1021/jo400834h
(2013)