Organic Letters
Letter
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condition, where a diverse array of α-keto acids and 2H-
indazoles are used as a tool for the structural diversification of
3-acyl-2H-indazoles. Our three-point structural variation studies
map out the importance of electronic features in the α-keto
acids and 2H-indazoles. With direct synthetic access to 3-acyl-
2H-indazoles, the medicinal chemistry aspect of 3-acyl-2H-
indazoles can be now examined. Additional biological studies of
thus-prepared 2H-indazole derivatives, as well as the extension
of radical addition reactions to other heteroaromatic com-
pounds, are currently underway, and our results will be
reported in due course.
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ez-Villanueva, J.; Yepez-
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Rodríguez-Vicente, A. K.; Cortes
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Estrada-Castro, D. B. Synthesis and Biological Evaluation of 2H-
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(h) Xu, L.; Peng, Y.; Pan, Q.; Jiang, Y.; Ma, D. Assembly of Substituted
3-Aminoindazoles from 2-Bromobenzonitrile via a CuBr-catalyzed
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ASSOCIATED CONTENT
* Supporting Information
The Supporting Information is available free of charge on the
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S
Experimental procedures and characterization data for all
AUTHOR INFORMATION
■
Corresponding Author
ORCID
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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The authors thank Dr. Yogesh Goriya (Chung-Ang University)
for a preliminary investigation. This research was supported by
the National Research Foundation of Korea (NRF) grants
funded by the Korean government (MSIP) (Nos. NRF-
2015R1A5A1008958 and NRF-2015R1C1A2A01053504).
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