M. Ignacak, J. Starzyk, H. Dziatkowiak, et al.
10. Latronico A.C, Anasti J., Arnhold I.J.P., et al. A novel mu-
tation of the luteinizing hormone receptor gene causing
male gonadotropin-independent precocious puberty.
J. Clin. Endocrinol. Metab. 1995, 80: 2490-2494.
only non-European country where this mutation has
been found is Japan (17). Our two families with male-
limited precocious puberty triggered by Met398Thr
substitution add to the short list of cases of the famil-
ial form of MPP and were the only ones described in
Eastern Europe. The presence of mutation in the pa-
tient’s 4 sisters opens the possibility of spreading this
type of mutation in the country of Poland.
11. Gromoll J., Partsch C.J., Simoni M., et al. A mutation in
the first transmembrane domain of the lutropin receptor
causes male precocious puberty. J. Clin. Endocrinol.
Metab. 1998, 83: 476-480.
12. Kraaij R., Post M., Kremer H., et al. A missense mutation in
the second transmembrane segment of the luteinizing hor-
mone receptor causes familial male-limited precocious pu-
berty. J. Clin. Endocrinol. Metab. 1995, 80: 3168-3172.
ACKNOWLEDGEMENTS
Supported by grant No 4PO5-E-058-18 from the State Com-
mittee for Scientific Research. Editorial assistance of Mr. I.
Coridano is gratefully acknowledged.
13. Latronico A.C., Abell A.N., Arnhold I.J., et al. A unique
constitutively activating mutation in third transmembrane
helix of luteinizing hormone receptor causes sporadic male
gonadotropin-independent precocious puberty. J. Clin.
Endocrinol. Metab. 1998, 83: 2435-2440.
14. Schedewie H.K., Reiter E.O., Beitins I.Z., et al. Testicular
Leydig cell hyperplasia as a cause of familial sexual pre-
cocity. J. Clin. Endocrinol. Metab. 1981, 52: 271-278.
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